Wow a new cosmetic dentists site. How cool is that! It will be very interesting to watch this one grow into a big beautiful site. Cosmetic dentistry is such a popular thing these days. It used to be for movie stars and politicians but with the advances in technology and the lowering of prices, many people are able to beautify their smile with some fancy dentistry.
The best cosmetic dentists in Minnesota! Great new website! You can tell it's very new and not completely filled out yet, but that's okay. It will be fun to follow along and see the progress that's made when this new site continues to be filled out and grows with more content. It is interesting to see that there has also been some interesting facts posted about the state of Minnesota. I did not know most of these! It's worth the read just to find out these juicy tidbits.
A new website about the best cosmetic dentists in Florida. That's something very interesting. No doubt it's a brand new website, as it is not all decked out with information yet. But I imagine it will be all filled out soon, including great pictures and all the bells and whistles. It's pretty exciting to see a new website in the making and watch it as it progresses through all the stages.
A Hawaii born surfer gets attacked by a great white shark while surfing off the Oregon Coast. His friend witnessed the attach. The great white chomped off a 2-foot chunk off the end of the board and gobbled it down. Fortunately for the surfer, he escaped and made it to shore. That must have been the scare of a lifetime. Apparently he is an awesome short-board surfer but isn't too sure he will ever surf again.
His wife and 5 children must be really counting their lucky stars right now.
This article is very interesting! The research scientists deem the malaria-carrying mosquito to be the world's most dangerous animal based on how many humans it kills per year. It works out to be one child death per 45 seconds in Africa. That is astounding, and in a bad way of course.
It is estimated that malaria costs Africa's economy $12 billion per year. The cost of human lives of course is a heavier burden. It would be wonderful to completely eradicate malaria.
ScienceDaily (Oct. 21, 2011) — Researchers from the NYU Cancer Institute, an NCI-designated cancer center at NYU Langone Medical Center, have identified a cell cycle-regulated mechanism behind the transformation of normal cells into cancerous cells. The study shows the significant role that protein networks can play in a cell leading to the development of cancer. The study results, published in the October 21 issue of the journal Molecular Cell, suggest that inhibition of the CK1 enzyme may be a new therapeutic target for the treatment of cancer cells formed as a result of a malfunction in the cell's mTOR signaling pathway.
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In the study, NYU Cancer Institute researchers examined certain multi-protein complexes and protein regulators in cancer cells. Researchers identified a major role for the multi-protein complex called SCFβTrCP. It assists in the removal from cancer cells the recently discovered protein DEPTOR, an inhibitor of the mTOR pathway. SCF (Skp1, Cullin1, F-box protein) ubiquitin ligase complexes are responsible for the removal of unnecessary proteins from a cell. This degradation of proteins by the cell's ubiquitin system controls cell growth and prevents malignant cell transformation. Researchers show that inhibiting the ability of SCFβTrCPto degrade DEPTOR in cells can result in blocking the proliferation of cancer cells. In addition, researchers discovered that the activity of CK1 (Casein Kinase 1), a protein that regulates signaling pathways in most cells, is needed for SCFβTrCP to successfully promote the degradation of DEPTOR.
"Low levels of DEPTOR and high levels of mTOR activity are found in many cancers, including cancers of the breast, prostate, and lung," said senior study author Michele Pagano, MD, the May Ellen and Gerald Jay Ritter Professor of Oncology and Professor of Pathology at NYU Langone Medical Center and a Howard Hughes Medical Institute Investigator. "It is critical for researchers to better understand how the protein DEPTOR is regulated.Our study shows it would be advantageous to increase the levels of DEPTOR in many types of cancer cells to inhibit mTOR and prevent cell proliferation."
The mTOR pathway (mammalian Target Of Rapamycin) regulates the growth, proliferation, and survival of a cell, and its proper regulation is essential to prevent the formation of cancer cells. DEPTOR interrupts the mTOR pathway by binding to mTOR protein complexes and blocking their enzymatic activities, restraining cell growth. This helps support the proliferation and survival of cancer cells.
Study experiments showed that a reduction of SCFβTrCP and CK1 proteins in cells resulted in accumulation of DEPTOR. Also, DEPTOR was destroyed in cells only when SCFβTrCP and CK1 were both present. Thus, inhibition of SCFβTrCP or CK1 represents a novel and promising way to inhibit the mTOR pathway. A pharmacologic inhibitor of CK1 was tested by researchers and shown to successfully stabilize DEPTOR in cells, while other pharmacological agents had no effect.
"Our study findings demonstrate that DEPTOR is regulated by the SCFβTrCPprotein complex in cells reentering the cell cycle, and deregulation of this event could contribute to the aberrant activation of the mTOR pathway in cancer," said lead author Shanshan Duan, PhD, a post-doctoral fellow in the Department of Pathology at NYU School of Medicine in Dr. Pagano's Laboratory. "This study suggests a novel approach to stop the deregulation of the mTOR pathway in cancer cells with promising small molecule inhibitors of CK1.This study is another step forward in the translation of laboratory findings into more effective approaches to cancer prevention and treatment."
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The above story is reprinted from materials provided by NYU Langone Medical Center / New York University School of Medicine.
Note: ScienceDaily reserves the right to edit materials for content and length. For further information, please contact the source cited above.
Journal References:
- Shanshan Duan, Jeffrey R. Skaar, Shafi Kuchay, Alfredo Toschi, Naama Kanarek, Yinon Ben-Neriah, Michele Pagano. mTOR Generates an Auto-Amplification Loop by Triggering the βTrCP- and CK1α-Dependent Degradation of DEPTOR. Molecular Cell, 2011; 44 (2): 317-324 DOI: 10.1016/j.molcel.2011.09.005
- Shanshan Duan, Jeffrey R. Skaar, Shafi Kuchay, Alfredo Toschi, Naama Kanarek, Yinon Ben-Neriah, Michele Pagano. mTOR Generates an Auto-Amplification Loop by Triggering the βTrCP- and CK1α-Dependent Degradation of DEPTOR. Molecular Cell, 21 October 2011; 44(2) pp. 317 - 324 DOI: 10.1016/j.molcel.2011.09.005
Note: If no author is given, the source is cited instead.
Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.
Even though this article is written with a lot of technical terms in it, at the same time it gives hope in new research understanding cancer development. Cancers of many kinds are leading causes of death in the developed world.
The more we understand about how cancer develops in the cell and how those first steps of development can be prevented, the closer we will be to eradicating cancer all together. It is very exciting.
The X Factor. It has been quite a wild ride so far for some of the contestants. It is so interesting to follow along and see all the different personalities they all have. The struggles and the dreams. There is so much more to each one of them than just the voice.
Some of them have a voice that just speaks for itself, and others have to rely on their personality to supplement their voice.
But it's a fun show to watch and follow along with. The baseball games have been conflicting with X Factor air times, but I'm sure they will figure it out.
This article is titled, "You Can Wash Away Your Troubles, With Soap". What makes it so interesting is that it is based on a psychological presumption that washing your hands can also have the psychological effect of washing away guilt.
So when you hear the saying "I have washed my hands of it", the person is using a psychological tool to try to dissuade feelings of guilt or remorse.
I was surprised to find such an article in Science Daily, because they are usually about scientific rather than psychological subjects. Where science can be based more solidly in fact, psychologically-based theories have more room for individual interpretation.
Very interesting article. Well worth the time to read it.
We have been eating so many more greens lately, and we all feel better! We have always been somewhat of a veggie family anyway, but now we are making more of a concerted effort to fit even more fresh vegetables into our daily diets. I am convinced that's one of the biggest contributing factors to my grandma's old age and healthy state into her mid 90's. If it hadn't been for the post-polio syndrome that popped up and eventually claimed her life, I think she would have lived even longer and retained good health right to the end.
The science daily article is actually about how pale-skinned people may need vitamin D supplements because they might be unable to spend enough time in the sun to make sufficient vitamin D for their bodies needs.
This looks exquisite. And found on the same morning I said to my children, I'm so sick of having the same foods for breakfast all the time, aren't you? Let's look for some dishes from other countries that we can try for a change for breakfast. Who's game? Well, I only asked 2 of my 6 children this question, and they were both quite game for it. It's a couple of the younger ones I will have my doubts about. I don't think they're quite game for any kind of change in breakfast food.
While cold cereal is a stranger to our table, especially in the winter, it does make for a nice change once in a while. It's trying to find a healthy one on sale that becomes the tricky part.
So, I guess it's back to oatmeal or red river cereal, toast or a homemade muffin, and scrambled eggs. (And maybe a little Dim Begun for the older ones!)
